Orangeburg - Hardcoverby Gene Atkinson (Author) Located along the north fork of South Carolina's Edisto River, Orangeburg enjoys an extended, rich heritage dating back to the 1730s when it was created as one of the original inland townships. The first settlers were mostly German and Swiss immigrants who found the area to be the paragon of locales, valuable in fertile soil and abundant wildlife surrounding the river. The city of today has been gently shaped by its landscape