St. Ephrem Custom MedalAvailable in Sterling Silver, 14kt Yellow Gold, and 14kt Gold Filled. Three sizes to choose from: Large: 1 x 3 4 inch Standard: 3 4 x 1 2 inch Charm: 1 2 x 1 4 inch Ephrem fled his home city of Nisibis when Emperor Constantine I died and the Persians beseiged it. Settling in Edessa, he worked as a teacher, writing several hundred hymns and writings. His poetry, homilies and sermons lead to the first instance of singing in public worship. Born: circa